Blog Portugal: Cardene SR

Generic Name: nicardipine (Oral route)

nye-kar-di-peen

Commonly used brand name(s)

In the U.S.

Cardene

Cardene SR

Available Dosage Forms:

Capsule, Extended Release

Capsule

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Dihydropyridine

Uses For Cardene SR

Nicardipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Nicardipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nicardipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload .

This medicine is available only with your doctor's prescription .

Before Using Cardene SR

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nicardipine in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nicardipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require an adjustment of dose in patients receiving nicardipine .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Levomethadyl

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amiodarone

Atazanavir

Dantrolene

Droperidol

Everolimus

Fentanyl

Vecuronium

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Alprenolol

Atenolol

Betaxolol

Bevantolol

Bisoprolol

Bucindolol

Carteolol

Carvedilol

Celiprolol

Cyclosporine

Dalfopristin

Dilevalol

Esmolol

Fluconazole

Indinavir

Itraconazole

Ketoconazole

Labetalol

Levobunolol

Magnesium

Mepindolol

Metipranolol

Metoprolol

Nadolol

Nebivolol

Oxprenolol

Penbutolol

Pindolol

Propranolol

Quinupristin

Rifapentine

Sotalol

St John's Wort

Talinolol

Tertatolol

Timolol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper Use of nicardipine

This section provides information on the proper use of a number of products that contain nicardipine. It may not be specific to Cardene SR. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet .

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain:
- For oral dosage form (capsules):
  - Adults—At first, 20 milligrams (mg) three times a day. Your doctor may increase your dose if needed.
  - Children—Use must be determined by your doctor .

For high blood pressure:
- For oral dosage form (capsules):
  - Adults—At first, 20 milligrams (mg) three times a day. Your doctor may increase your dose if needed.
  - Children—Use must be determined by your doctor .
- For oral dosage form (extended-release capsules):
  - Adults—At first, 30 milligrams (mg) two times a day. Your doctor may increase your dose if needed.
  - Children—Use must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Cardene SR

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

Cardene SR Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Arm, back, or jaw pain

chest pain or discomfort

chest tightness or heaviness

fast or irregular heartbeat

nausea

palpitations

shortness of breath

sweating

swelling of the legs

Less common

Shakiness

swelling

Rare

Blurred vision

cold hands and feet

cold sweats

confusion

cough or hoarseness

difficulty swallowing

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

extra heartbeat

fever or chills

hives

increase in frequency of urination

itching

lower back or side pain

painful or difficult urination

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

skin rash

unusual tiredness or weakness

wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Sleepiness

slurred speech

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Feeling of warmth

headache

lack or loss of strength

redness of the face, neck, arms and occasionally, upper chest

Less common

Acid or sour stomach

belching

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

difficulty in moving

dry mouth

heartburn

indigestion

joint pain

muscle aching or cramping

muscle pains or stiffness

rash

stomach discomfort, upset, or pain

swollen joints

Rare

Changes in vision

constipation

continuing ringing or buzzing or other unexplained noise in ears

decreased interest in sexual intercourse

difficult or labored breathing

discouragement

fear or nervousness

feeling of constant movement of self or surroundings

feeling sad or empty

hearing loss

inability to have or keep an erection

increase in body movements

irritability

lack of appetite

loss of interest or pleasure

loss in sexual ability, desire, drive, or performance

nervousness

pain or tenderness around eyes and cheekbones

runny nose

sensation of spinning

sneezing

sore throat

stuffy nose

trouble concentrating

trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cardene SR side effects (in more detail)

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More Cardene SR resources

Cardene SR Side Effects (in more detail)
Cardene SR Use in Pregnancy & Breastfeeding
Drug Images
Cardene SR Drug Interactions
Cardene SR Support Group
0 Reviews for Cardene SR - Add your own review/rating

Cardene SR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Cardene SR Prescribing Information (FDA)

Cardene SR Concise Consumer Information (Cerner Multum)

Cardene Prescribing Information (FDA)

Cardene Monograph (AHFS DI)

Cardene MedFacts Consumer Leaflet (Wolters Kluwer)

Cardene IV MedFacts Consumer Leaflet (Wolters Kluwer)

Nicardipine Prescribing Information (FDA)

Compare Cardene SR with other medications

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Blog Portugal

Thursday, September 22, 2016

Cardene SR